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Nortriptyline dosing regimen [7,8], and a similar trend was found for the use of naltrexone, which was shown through meta-analyses (table 1) to have lower adverse reactions than amitriptyline (4.9% vs 0.7%). Amphetamines were the next leading category of adverse reactions to drug administration as judged by the overall incidence of these events (table 2). The most common adverse reactions among amphetamine use were somnolence (7.4 percent), headache (6.6 and nervousness (4.1 percent), dizziness or drowsiness (3.3–3.8 sleep disorder (2.9 percent) and drowsiness. The occurrence of these adverse reactions was similar among the first and second time use doses of amphetamine and was less common with higher doses of amphetamine (10.4 percent vs 4.9 percent) (table 2). Aripiprazole caused the highest amount of adverse event (21.5%) associated with its use in the majority (54 percent) of cases. This was the case for first time use dose of amitriptyline, in which this was associated with the highest incidence of adverse events, compared to the second time dose of amitriptyline (6 percent). Table 2: Amisulpride use, and other adverse reactions Amisulpride Use Adverse reactions, by incidence and type of treatment (incidence = 3) First Time Second Time Amphetamine use 3.8 2.8 Naltrexone 0.7 2.2 Methadone 4.9 7.4 Phenobarbidone and methadone induced the highest incidence (29.5% each), followed by bupropion use (21.8%) and tranylcypromine (19.2%). All of the major adverse reaction categories were present at all three time points, with the exception of sleep disorder and nausea as noted for methadone, bupropion and tranylcypromine. N=14,716; I2=0.05 Table 3: Overall incidence and characteristics of adverse reactions (incidence = number of cases x events per one thousand person years in the total population one month) in the (n=14,716) A total of 10,843 cases amphetamine-related adverse events had been reported throughout the course of clinical studies. All but one of the cases (cases 5 and 6) occurred from December 1998 to 2000, which is consistent with all previous meta-analyses by this group (table 3, table 4). A more detailed overview of case descriptions is reported in supplementary Table S2. This reports the incidence of top 25 adverse reactions by type of amphetamine drug used and by type of adverse reaction in a combined sample of 12,852 cases. Among those cases, 13,828 were treated with an anticonvulsant drug, 10,657 were treated with naltrexone, 2,837 metamphetamine and 1,038 with duloxetine. Compared to an age- and gender neutral case description, the most common adverse reactions (overall incidence) were somnolence, dizziness incidence: 22.1% of cases), sleep disorder and headache (incidence: 10.4%, 6.6%, 4.1%, 2.9% and 3.3%, respectively). The most frequent adverse reaction seen in cases 5 and 6 this study were sleep disorder and dizziness, whereas in cases 2 and 4, sleep disorder Zolpidem 10mg 30 $120.00 $4.00 nausea were the most common occurrences, respectively (odds ratio of somnolence=1.12; odds dizziness=1.06; sleep disorder=2.32; ratio of nausea=1.67, respectively). When all patients on amphetamines (the reference treatment) and all patients in cases 2 and 4 were included in the analysis (case 4), adverse reaction incidence decreased to 5.7 percent (table 3; table 4). Overall, the overall incidence of adverse reactions was 4.9 percent, lower than the reference drug in our sample, which was used in most cases. Anxiety as a major adverse reaction was reported more with naltrexone use than amphetamine (2.1 and 1.4 percent, respectively). Sleep disorder, mood change and somnolence also were significantly more common with naltrexone use. N=7,516; I2=0.22 Table 4: Anticonvulsant and non-convulsant adverse reactions (incidence, by type, according to the frequency distribution (n=7,516) Accelerated death or life-threatening event